* * * * *
Titanium and its alloys are widely used in implants due to their excellent
biocompatibility. Today, these devices are far from perfect and need significant
improvement.
In particular, the surface physicochemical characteristics of the implant
determine the interface conditions with the host tissue and have to be
properly defined. By biochemical modifications proteins, enzymes, or peptides
can be immobilized on the surface of biomaterials for the purpose of inducing
specific cell and tissue responses or, in other words, controlling the
tissue-implant bonding with molecules delivered directly to the interface.
This methodology has great potential for controlling initial bone-implant
interactions.
Additionally, it has been shown that increased osteoblast (bone-forming
cells) adhesion can be achieved on nanostructured materials, in parallel
with decreased functions of competitive cells such as fibroblasts (cells
that contribute to fibrous encapsulation and callus formation events that
may lead to implant loosening and failure).
My research aims at combining the nanoscale approach with biochemical
modifications of the surface in order to create novel biomaterials with
improved performances.
PUBLICATIONS
7) STM observations of co-adsorbed single-walled carbon nanotubes with
benzoic acid molecules
C. Rabot, S. Clair, Y. Kim, M. Kawai, Japanese Journal
of Applied Physics, in press (2007)
6) Adsorption mechanism of aligned single wall carbon nanotubes at well
defined metal surfaces
S. Clair, C. Rabot, Y. Kim, M. Kawai, Journal of Vacuum
Science and Technology B 25, in press (2007)
5) Coexistence of one- and two-dimensional supramolecular assemblies
of terephthalic acid on Pd(111) due to self-limiting deprotonation
M. E. Cañas-Ventura, F. Klappenberger, S. Clair,
S. Pons, K. Kern, H. Brune, T. Strunskus, Ch. Wöll, R. Fasel, J.
V. Barth, Journal of Chemical Physics 125, 184710 (2006)
4) Monitoring two-dimensional coordination reactions: directed assembly
of Co-terephthalate nanosystems on Au(111)
S. Clair, S. Pons, S. Fabris, S. Baroni, H. Brune, K.
Kern, J.V. Barth, Journal of Physical Chemistry B 110, 5627(2006)
3) Mesoscopic metallosupramolecular texturing through hierarchic assembly
S. Clair, S. Pons, H. Brune, K. Kern, J.V. Barth, Angewandte
Chemie International Edition 44, 7294 (2005)
2) STM study of terephthalic acid self-assembly on Au(111): hydrogen-bonded
sheets on an inhomogeneous substrate
S. Clair, S. Pons, A. P. Seitsonen, H. Brune, K. Kern,
J.V. Barth, Journal of Physical Chemistry B 108, 14585 (2004)
1) Electron energy-loss spectroscopy fine structure of the Cu L2,L3 ionization
edge in substitutional Cu-Ni Alloys
C. Hébert, S. Clair, C. Eisenmenger-Sittner, H.
Bangert, B. Jouffrey, P. Schattschneider, Journal of Physics - Condensed
Matter 13 (16), 3791 (2001)
|
