Titanium (Ti) and its alloys are widely
used in implants due to their excellent biocompatibility. Furthermore,
because of their excellent mechanical strength, they are frequently used
in load bearing situations. However, these devices are from far from perfect
and need significant improvement. Depending on the patient’s overall
health, the prosthesis may eventually require revision.
To improve implants, it is essential to engineer biomaterials in ways
that promote tissue integration and improve biological function. The key
to the design of novel biomaterials is to properly manage the interaction
of the surface and the interface between the material and the host tissue
since in the human body, most reactions occur at surface and interfaces.
A long-standing hypothesis asserts that four surface properties control
events at tissue-implant surfaces: (i) composition, (ii) energy, (iii)
roughness, and (iv) topography. Various surface textures have been used
to stimulate cell and tissue responses yet there is no agreement on which
features optimize cellular reactions. The objective of my project is to
develop nanotechnology-based strategies that will lead to a new generation
of biomaterials with intelligent surfaces. These will actively influence
their environment and interact with tissues to control cell adhesion and
proliferation at surfaces.
Such intelligent surfaces may be used for various applications, including
implantable biomaterials as well as drug delivery and biosensors, with
broad implications and a significant impact in nanomedicine.
PUBLICATION LIST
A. Invited Reviews
[A2] F. Vetrone, J. C. Boyer and J. A. Capobianco, Yttrium
Oxide Nanocrystals: Luminescent Properties and Applications, In The Encyclopedia
of Nanoscience and Nanotechnology, Edited by H. S. Nalwa, American Scientific
Publishers, Stevenson Ranch, CA, Vol. 10, pp. 725-765 (2004)
[A1] F. Vetrone, J. C. Boyer and J. A. Capobianco, Luminescence,
Optical Spectroscopy, and Applications of Rare Earth Doped Y2O3 Nanocrystals,
In The Handbook of Luminescence, Display Materials and Devices, Edited
by H. S. Nalwa and L. Shea Rohwer, American Scientific Publishers, Los
Angeles, CA, Vol. 2, Chapter 3, pp. 141-186 (2003)
B. Refereed Journal Publications
[B23] F. Pandozzi, F. Vetrone, J. C. Boyer, R. Naccache,
J. A. Capobianco, A. Speghini and M. Bettinelli, A Spectroscopic Analysis
of Blue and Ultraviolet Upconverted Emissions from Gd3Ga5O12:Tm3+, Yb3+
Nanocrystals, J. Phys. Chem. B, 109; 17400-17405 (2005)
[B22] F. Vetrone, J. C. Boyer, J. A. Capobianco, A. Speghini
and M. Bettinelli, R. Krsmanovic and S. Polizzi, Structural Investigation
and Anti-Stokes Emission of Scandium Oxide Nanocrystals Activated with
Trivalent Erbium, J. Electrochem. Soc., 152; H19-H24 (2005)
[B21] J. C. Boyer, F. Vetrone, J. A. Capobianco, A. Speghini
and M. Bettinelli, Variation of Fluorescence Lifetimes and Judd-Ofelt
Parameters Between Eu3+ Doped Bulk and Nanocrystalline Cubic Lu2O3, J.
Phys. Chem. B, 108; 20137-20143 (2004)
[B20] F. Vetrone, J. C. Boyer, J. A. Capobianco, A. Speghini
and M. Bettinelli, Wet Chemical Synthesis and Luminescence Properties
of Erbium Doped Nanocrystalline Yttrium Oxide, J. Mater. Res., 19; 3398-3407
(2004)
[B19] R. Naccache, F. Vetrone, J. C. Boyer, J. A. Capobianco,
A. Speghini and M. Bettinelli, Visible Upconversion Emission of Pr3+ Doped
Gadolinium Gallium Garnet (GGG) Nanocrystals, J. Nanosci. Nanotechno.,
4; 1025-1031 (2004)
[B18] F. Vetrone, J. C. Boyer, J. A. Capobianco, A. Speghini
and M. Bettinelli, Significance of Yb3+ Concentration on the Upconversion
Mechanisms in Codoped Y2O3:Er3+, Yb3+ Nanocrystals, J. Appl. Phys., 96;
661-667 (2004)
[B17] R. Naccache, F. Vetrone, J. C. Boyer, J. A. Capobianco,
A. Speghini, M. Bettinelli and G. C. Righini, Upconversion Luminescence
of a Calcium Sodium Aluminosilicate Glass Doped with Erbium, Mater. Lett.,
58; 2207-2212 (2004)
[B16] J. C. Boyer, F. Vetrone, J. A. Capobianco, A. Speghini
and M. Bettinelli, Yb3+ Ion As a Sensitizer for the Upconversion Luminescence
in Nanocrystalline Gd3Ga5O12:Ho3+, Chem. Phys. Lett., 390; 403-407 (2004)
[B15] J. C. Boyer, F. Vetrone, J. A. Capobianco, A. Speghini,
M. Zambelli and M. Bettinelli, Investigation of the Upconversion Processes
in Nanocrystalline Gd3Ga5O12:Ho3+, J. Lumin., 106; 263-268 (2004)
[B14] S. Polizzi, S. Bucella, A. Speghini, F. Vetrone,
R. Naccache, J. C. Boyer and J. A. Capobianco, Nanostructured Lanthanide-Doped
Lu2O3 Obtained by Propellant Synthesis, Chem. Mater., 16; 1330-1335 (2004)
[B13] M. Zambelli, A. Speghini, G. Ingletto, M. Bettinelli, F.
Vetrone, J. C. Boyer and J. A. Capobianco, Optical Spectroscopy
of Lanthanide Ions in Al2O3 - Nb2O5 - TeO2 Glasses, Opt. Mater., 25; 215-222
(2004)
[B12] F. Vetrone, J. C. Boyer, J. A. Capobianco, A. Speghini
and M. Bettinelli, A Spectroscopic Investigation of Trivalent Lanthanide
Doped Y2O3 Nanocrystals, Nanotechnology, 15; 75-81 (2004)
[B11] F. Vetrone, J. C. Boyer, J. A. Capobianco, A. Speghini
and M. Bettinelli, Luminescence Spectroscopy and Near-Infrared to Visible
Upconversion of Nanocrystalline Gd3Ga5O12:Er3+, J. Phys. Chem. B, 107;
10747-10752 (2003)
[B10] F. Vetrone, J. C. Boyer, J. A. Capobianco, A. Speghini
and M. Bettinelli, Concentration Dependent Near Infrared-to-Visible Upconversion
in Nanocrystalline and Bulk Y2O3:Er3+, Chem. Mater., 15; 2737-2743 (2003)
[B9] J. C. Boyer, F. Vetrone, J. A. Capobianco, A. Speghini
and M. Bettinelli, Optical Transitions and Upconversion Properties of
a Ho3+ doped ZnO-TeO2 glass, J. Appl. Phys., 93; 9460-9465 (2003)
[B8] F. Vetrone, J. C. Boyer, J. A. Capobianco, A. Speghini
and M. Bettinelli, Effect of Yb3+ Co-doping on the Upconversion Emission
in Nanocrystalline Y2O3:Er3+, J. Phys. Chem. B, 107; 1107-1112 (2003)
[B7] F. Vetrone, J. C. Boyer, J. A. Capobianco, A. Speghini
and M. Bettinelli, NIR to Visible Upconversion in Nanocrystalline and
Bulk Lu2O3:Er3+, J. Phys. Chem. B, 106; 5622-5628 (2002)
[B6] J. A. Capobianco, J. C. Boyer, F. Vetrone, A. Speghini
and M. Bettinelli, Optical Spectroscopy of Bulk and Nanocrystalline Cubic
Y2O3:Ho3+, Chem. Mater., 14; 2915-2921 (2002)
[B5] F. Vetrone, J. C. Boyer, J. A. Capobianco, A. Speghini
and M. Bettinelli, 980 nm Upconversion in an Er - doped ZnO-TeO2 Glass,
Appl. Phys. Lett., 80; 1752-1754, (2002)
[B3] J. A. Capobianco, F. Vetrone, J. C. Boyer, A. Speghini
and M. Bettinelli, Enhancement of Red Emission (?F9/2 ? ??15/2? via Upconversion
in Bulk and Nanocrystalline Cubic Y2O3:Er3+, J. Phys. Chem. B, 106; 1181-1187
(2002)
[B2] J. A. Capobianco, F. Vetrone, J. C. Boyer, A. Speghini
and M. Bettinelli, Visible Upconversion of Er3+ doped Nanocrystalline
and Bulk Lu2O3, Opt. Mater., 19; 259-268 (2002)
[B1] J. A. Capobianco, F. Vetrone, T. D’Alesio,
G. Tessari, A. Speghini and M. Bettinelli, Optical Spectroscopy of Nanocrystalline
Cubic Y2O3:Er3+ Obtained by Combustion Synthesis, Phys. Chem. Chem. Phys.,
2; 3203-3207 (2000)
|
