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Fabio Variola

PHD Student

Université du Québec
Institut national de la recherche scientifique
Énergie, Matériaux et Télécommunications
1650, boulevard Lionel-Boulet
Varennes, Québec, Canada
J3X 1S2

Telephone: +1 (450) 929-8237
Fax: +1 (450) 929-8102
variola@emt.inrs.ca
www.emt.inrs.ca

 
Cellular response to nanostructured biocompatible materials

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The specific goal of my proposed research is to develop and apply strategies based on nanotechnology to create a new generation of surfaces that have tailor–made chemical–physical properties for applications in various sectors, and particularly in health, including for example biosensors, drug delivery, orthopaedic and dental implants. Major opportunities for improving human health will be created by learning how to make surfaces with controlled nanoscale features. Nanostructured surfaces are substrates with imprinted or patterned features with dimensions 100 nm or less. Such systems are widely studied because they exhibit novel, unexpected properties by virtue of their reduced dimensionality. We propose to discover new methods for nanostructuring and nanopatterning suitable substrates as Titanium and other biocompatible materials for dental and orthopaedic applications, in ways that add new functionalities to the surfaces and optimize integration in vivo. In fact, such “intelligent” surfaces may be used to influence, lead and accelerate various biological processes such as bone cell adhesion and growth, typically referred to as tissue repair or regeneration.